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KMID : 1040620210270030463
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Clinical and Molecular Hepatology
2021 Volume.27 No. 3 p.463 ~ p.473
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Serum milk fat globule-EGF factor 8 protein as a potential biomarker for metabolic syndrome
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Lee Han-Ah
Lim Ji-Hwan
Joo Hyung-Joon
Lee Young-Sun
Jung Young-Kul
Kim Ji-Hoon
An Hyung-Gin
Yim Hyung-Joon
Jeen Yoon-Tae
Yeon Jong-Eun
Lim Do-Sun
Byun Kwan-Soo
Seo Yeon-Seok
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Abstract
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Background/Aims: Useful biomarkers for metabolic syndrome have been insufficient. We investigated the performance of serum milk fat globule-EGF factor-8 (MFG-E8), the key mediator of inflammatory pathway, in diagnosis of metabolic syndrome.
Methods: Subjects aged between 30 and 64 years were prospectively enrolled in the Seoul Metabolic Syndrome cohort. Serum MFG-E8 levels were measured at baseline.
Results: A total of 556 subjects were included, comprising 279 women (50.2%) and 277 men (49.8%). Metabolic syndrome was diagnosed in 236 subjects (42.4%), and the mean MFG-E8 level of subjects with metabolic syndrome was significantly higher than that of subjects without metabolic syndrome (P<0.001). MFG-E8 level was significantly correlated with all metabolic syndrome components and pulse wave velocity (all P<0.05). Subjects were categorized into two groups according to the best MFG-E8 cut-off value as follows: group 1, MFG-E8 level <4,745.1 pg/mL (n=401, 72.1%); and group 2, MFG-E8 level ≥4,745.1 (n=155, 27.9%). At baseline, metabolic syndrome in group 2 was significantly more prevalent than in group 1 (63.9% vs. 34.2%, P<0.001). During median follow-up of 17 months, metabolic syndrome developed in 122 (38.1%) subjects among 320 subjects without it at baseline. The incidence of metabolic syndrome in group 2 was significantly higher than that in group 1 (55.4% vs. 34.5%, P=0.003). On multivariate analysis, MFG-E8 level ≥4,745.1 pg/mL was an independent predictor for diagnosis and development of metabolic syndrome after adjusting other factors (all P<0.05).
Conclusions: Serum MFG-E8 level is a potent biomarker for the screening and prediction of metabolic syndrome.
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KEYWORD
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Milk fat globule-EGF factor-8, Metabolic syndrome, Biomarkers, Diagnosis
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